Mission: Impossible 2 (stylized as M:i-2) is a 2000 American spy action film directed by John Woo and produced by and starring Tom Cruise. The sequel to 1996’s Mission: Impossible, it is the second installment in the Mission: Impossible film series. It follows Ethan Hunt as he is recruited by the Impossible Missions Force (IMF) to find and destroy a dangerous biological weapon called “Chimera” from rogue IMF agent Sean Ambrose with the help of his new girlfriend Nyah Nordoff-Hall.
Bio-chemical expert Dr. Vladimir Nekhorvich sends a message to the IMF for Ethan Hunt, an old friend of his, warning that his employer, Biocyte Pharmaceuticals, forced him to develop a biological epidemic to profit from its remedy. He arranges to meet with Ethan to deliver the Chimera virus, and its cure, Bellerophon. With Ethan on vacation and incommunicado, the IMF sends agent Sean Ambrose disguised as Ethan to meet Nekhorvich on a passenger plane. Ambrose goes rogue, killing Nekhorvich and stealing Bellerophon before his men destroy the plane.
IMF Commander Swanbeck informs Ethan of the circumstances of Nekhorvich’s death and they determine Ambrose is responsible. Swanbeck tasks Ethan with recovering the virus and its cure, and has him recruit Nyah Nordoff-Hall, a professional thief presently operating in Seville, Spain. After recruiting Nyah and romancing her, Ethan finds out that she is Ambrose’s ex-girlfriend and he reluctantly convinces her to spy on Ambrose.
Ethan assembles his team, computer expert Luther Stickell and pilot Billy Baird, in Sydney, Australia, where Biocyte laboratories are located and Ambrose is staying. As Ethan stakes out Biocyte, Nyah rekindles her former relationship with Ambrose and relays information to Ethan’s team. At a horse racing event, Ambrose meets with Biocyte’s CEO, John C. McCloy. He shows McCloy a memory card video of Chimera affecting one of Nekhorvich’s colleagues before blackmailing McCloy into cooperating with him. Nyah steals the camera’s memory card and delivers it to Ethan. They learn that Chimera has a 20-hour dormant period before it causes death by mass destruction of the victim’s red blood cells. Bellerophon can only save the victim if used within that 20-hour window. When Nyah discreetly returns the memory card to Ambrose, he notices it is in the wrong pocket of his jacket.